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Antikörper

Phospho-Btk (Tyr223) (Clone: B4) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4029-20UL
200 µl
£1021,00
12-4029-200UL
Über dieses Produkt
SKU:
12-4029
Zusätzliche Namen:
Bruton tyrosine kinase; Tyrosine-protein kinase BTK; Agammaglobulinemia tyrosine kinase; ATK; AGMX1; B-cell progenitor kinase; BPK
translate.label.attr.clone:
BtkY223-B4
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
Btk is a major node in the B-cell receptor signaling pathway; where it regulates B cell maturation; activation; survival; differentiation; and proliferation. Btk is activated by Src family kinases; including Lyn; which phosphorylates Btk at Tyr551. Upon phosphorylation at this site; Btk is recruited to the plasma membrane where autophosphorylation at Tyr223 occurs. The Btk signaling pathway is a major target of small molecule inhibitors for B-cell lymphoma; autoimmune diseases; and non-Hodgkin's lymphomas. These inhibitors either form a covalent bond at Cys481 in the ATP-binding site or serve as reversible inhibitors that bind the SH3 pocket and stabilize inactive Btk.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr223 of human phospho Btk
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Peptide blocking flow cytometric analysis of U937 cells secondary antibody only negative control (light blue) or untreated (red) or IFNa + IL4 + pervanadate-treated (green) or untreated and blocked with phospho-peptide (black) or treated and blocked with phospho peptide (gold) or untreated and blocked with non-phospho peptide (dark blue) or treated and blocked with non-phospho peptide (purple) Phospho-Btk (Tyr223) antibody BtkY223-B4 at 0.025µg/mL.
Fig-3: Flow cytometric analysis of 3T3 cells secondary antibody only negative control (blue) or untreated (grey) or treated with IFNa + IL4 + pervanadate (orange) using 0.05 µg/mL isotype control or untreated (red) or treated (green) using Phospho-Btk (Tyr223) antibody BtkY223-B4 at 0.05µg/mL.
Fig-3: Flow cytometric analysis of 3T3 cells secondary antibody only negative control (blue) or untreated (grey) or treated with IFNa + IL4 + pervanadate (orange) using 0.05 µg/mL isotype control or untreated (red) or treated (green) using Phospho-Btk (Tyr223) antibody BtkY223-B4 at 0.05µg/mL.