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Antikörper

Phospho-PLCg2 (Tyr759) (Clone: G3) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4025-20UL
200 µl
£1021,00
12-4025-200UL
Über dieses Produkt
SKU:
12-4025
Zusätzliche Namen:
1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; PLC-IV; PLC-gamma-2; PLCG2
translate.label.attr.clone:
PLCG2Y759-G3
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
The PLC-gamma isoforms of the PI-PLC family of lipases are regulated by growth factor receptors and B- and T-cell antigen receptors. While PLCg1 is expressed ubiquitously; PLCg2 is predominantly expressed in liver cells. PLCg2 plays a dominant role in B-cell signaling. Btk directly phosphorylates PLCg2; though the Syk kinase and BLNK adaptor protein are required. Both Tyr753 and Tyr759 have been identified as important phosphorylation sites for PLCg2 activation in B-cells. PLCg2 missense mutations and genomic deletions have been identified autoinflammatory diseases in humans. These include gain-of-function mutations; such as S707T; that possibly introduce an additional phosphorylation site and increase basal PLCg2 activity.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCg2.
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Western blot analysis of Ramos cell extract untreated or treated with pervanadate using Phospho-PLCg2 (Tyr759) antibody PLCG2Y759-G3.
Fig-3: Flow cytometric analysis of NIH3T3 cells secondary antibody only negative control (blue) or 0.1 µg/mL of isotype control (orange) or treated with imatinib (red) or with pervanadate (green) using Phospho-PLCg2 (Tyr759) antibody PLCG2Y759-G3 at 0.1 µg/mL.
Fig-4: Western blot analysis of Ramos cell extract untreated or treated with pervanadate using 0.01 µg/mL Phospho-PLCg2 (Tyr759) antibody PLCg2Y759-G3 or Company C antibody at 0.06 µg/mL (manufacturer's recommended concentration) developed using the same exposure.
Fig-4: Western blot analysis of Ramos cell extract untreated or treated with pervanadate using 0.01 µg/mL Phospho-PLCg2 (Tyr759) antibody PLCg2Y759-G3 or Company C antibody at 0.06 µg/mL (manufacturer's recommended concentration) developed using the same exposure.