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Antikörper

Phospho-Stat6 (Tyr641) (Clone: G12) rabbit mAb

Produktgrößen
20 µl
£631,00
12-4017-20UL
200 µl
£1021,00
12-4017-200UL
Über dieses Produkt
SKU:
12-4017
Zusätzliche Namen:
Signal transducer and activator of transcription 6; IL-4 Stat
translate.label.attr.clone:
Stat6Y641-G12
Klonalität:
Monoclonal
Konjugat:
Unconjugated
Weitere Details:
The transcription factor Stat6 is a member of the signal transducers and activators of transcription (STAT) family of proteins. Stat6 is the only member of this family that is activated by interleukin-4 (IL-4); after which Stat6 is both tyrosine- and serine-phosphorylated by Jak kinases. The consensus Stat6 binding site TTCN4GAA is found in the promoters of many genes regulated by IL-4. In T lymphocytes; Stat6 is required for differentiation into Th2 cells in response to IL-4. Stat6 may play a role in solid tumorigenesis; a large immunohistochemistry study of Stat6 expression in over 2;000 tumor samples confirmed strong nuclear staining.
Format:
Purified
Host:
Rabbit
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
Isotyp:
Rabbit IgG1k
Reaktivitäten:
Human, Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig 2 : Western blot analysis of Daudi cell extract untreated or treated with IL-4 using 0.01µg/mL Phospho-Stat6 (Tyr641) antibody Stat6Y641-G12.
Fig-3: Flow cytometric analysis of NIH3T3 cells secondary antibody only negative control (blue) or 0.1 µg/mL of isotype control (orange) or treated with imatinib (red) or with pervanadate (green) using Phospho-Stat6 (Tyr641) antibody Stat6Y641-G12 at 0.1 µg/mL.
Fig-4: Western blot analysis of Daudi cell extract untreated or treated with IL-4 using 0.01 µg/mL Phospho-Stat6 (Tyr641) antibody Stat6Y641-G12 or Company C antibody at 0.05 µg/mL (manufacturer's recommended concentration) developed using the same exposure.
Fig-4: Western blot analysis of Daudi cell extract untreated or treated with IL-4 using 0.01 µg/mL Phospho-Stat6 (Tyr641) antibody Stat6Y641-G12 or Company C antibody at 0.05 µg/mL (manufacturer's recommended concentration) developed using the same exposure.
Fig-5: Flow cytometric analysis of Ramos cells secondary antibody only negative control (blue) or untreated (red) or treated with IL-4 (green) using Phospho-Stat6 (Y641) antibody Stat6Y641-G12 or Company C antibody at 0.5 µg/mL (manufacturer's recommended concentration).