Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Clone: A11) rabbit mAb SureLight 488 conjugate
Produktgrößen
10 Tests
£532,00
12-4008-10TESTS
100 Tests
£792,00
12-4008-100TESTS
Über dieses Produkt
- SKU:
- 12-4008
- Zusätzliche Namen:
- Mitogen-activated protein kinase 3; MAPK3; ERK2; p44-MAPK; PRKM3; Mitogen-activated protein kinase 1; MAPK1; ERK1; p42-MAPK; PRKM1; PRKM2
- translate.label.attr.clone:
- ERK12T202Y204-A11
- Klonalität:
- Monoclonal
- Konjugat:
- SureLight 488
- Weitere Details:
- Human Erk1 and Erk2 Ser/Thr kinases share 84% sequence identity and nearly all functions. These MAP kinases are activated in response to mitogens and growth factors as part of the Ras-Raf-MEK-ERK signal transduction cascade. This pathway regulates cell survival; differentiation; adhesion; cell cycle progression; and many other cellular processes. Upon phosphorylation; Erk1/2 translocate to the nucleus to activate transcription factors including c-Fos; Elk1; Ets1; and SP-1. There are more than 175 known cytoplasmic and nuclear substrates of Erk1/2. The Erk1/2 cascade is upregulated in many human cancers; even when oncogenic mutations are not found. Multiple small-molecule inhibitors of Erk1/2 have been developed; including ones targeting the ATP-binding site either competitively or irreversibly.
- Format:
- Conjugated
- Host:
- Rabbit
- Immunogen:
- A synthetic phospho-peptide corresponding to residues surrounding Thr202/Tyr204 of human phospho Erk1/2.
- Isotyp:
- Rabbit IgG1k
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 2-8[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg