Polyclonal Antibody to CADM1
Produktgrößen
25ug
£319,00
11-4037-25UG
100ug
£407,00
11-4037-100UG
Über dieses Produkt
- SKU:
- 11-4037
- Zusätzliche Namen:
- CADM1||IGSF4||IGSF4A||NECL2||SYNCAM||TSLC1
- Klonalität:
- Polyclonal
- Weitere Details:
- Cell Adhesion Molecule 1 (CADM1) encodes a multifunctional immunoglobulin-like cell adhesion molecule whose cytoplasmic domain contains a type II PSD95/Dlg/ZO-1 (PDZ)-binding motif (BM) for associating with other intracellular proteins. CADM1 lacks expression in T lymphocytes of healthy individuals and is overexpressed in adult T-cell leukemia-lymphoma (ATL) cells. CADM1 generates a membrane-associated C-terminal fragment, AlphaCTF, through A disintegrin- and metalloprotease-10-mediated ectodomain shedding, subsequently releasing the intracellular domain (ICD) through gamma-secretase-mediated intramembrane shedding of alphaCTF. alphaCTF localizes to mitochondria and induces apoptosis in lung epithelial cells. In women with multiple cervical biopsies, CADM1/MAL methylation increases with severity of the lesion and is lesion-specific. CADM1/MAL methylation status in cervical scrapes appears to be representative of the worst underlying lesion, particularly for CIN3 and cervical cancer.
- Format:
- Purified
- Gendetails:
- CADM1
- Host:
- Rabbit
- Immunogen:
- A partial length recombinant CADM1 protein (amino acids 50-250) was used as the immunogen for this antibody.
- Isotyp:
- Rabbit IgG
- Aufreinigung:
- Protein A Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg