Polyclonal Antibody to IMPDHII
Produktgrößen
25ug
£319,00
11-3029-25UG
100ug
£407,00
11-3029-100UG
Über dieses Produkt
- SKU:
- 11-3029
- Zusätzliche Namen:
- IMPDH2||IMPD2
- Klonalität:
- Polyclonal
- Weitere Details:
- IMPDH2 (Human type II inosine monophosphate dehydrogenase) is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. The enzymatic reaction involves the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. It is increased more than 10-fold in activated peripheral blood T lymphocytes and is required for T cell activation. Type II isoform of the enzyme is selectively upregulated in neoplastic fast replicating lymphocytes and CML cancer cells. Thus, the IMPDH2 is an excellent target for antileukemic agent.
- Format:
- Purified
- Gendetails:
- IMPDH2
- Host:
- Rabbit
- Immunogen:
- A partial length recombinant IMPDHII protein (amino acids 48-351) was used as the immunogen for this antibody.
- Isotyp:
- Rabbit IgG
- Aufreinigung:
- Protein A Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg