Polyclonal Antibody to DUBA
Produktgrößen
25ug
£319,00
11-3014-25UG
100ug
£407,00
11-3014-100UG
Über dieses Produkt
- SKU:
- 11-3014
- Zusätzliche Namen:
- OTUD5
- Klonalität:
- Polyclonal
- Weitere Details:
- DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.
- Format:
- Purified
- Gendetails:
- OTUD5
- Host:
- Rabbit
- Immunogen:
- A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody.
- Isotyp:
- Rabbit IgG
- Aufreinigung:
- Protein A Chromatography
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Polyclonal Antibody
- Datenblatt des Herstellers:1.jpg