Monoclonal antibody to mouse OX40 (CD134) (Clone: OX-86)
Produktgrößen
100ug
£396,00
10-7662-100UG
Über dieses Produkt
- SKU:
- 10-7662
- Zusätzliche Namen:
- OX40 antigen; OX40L receptor; Ox40; Txgp1
- translate.label.attr.clone:
- OX-86
- Klonalität:
- Monoclonal
- Weitere Details:
- The OX-86 monoclonal antibody reacts with mouse OX-40 also known as CD134. OX-40 is a 50 kDa type I membrane glycoprotein and a member of the TNF receptor superfamily. OX-40 is expressed on activated CD4 and CD8 T cells, but is not found on resting naive T cells or most resting memory T cells. Although it was originally thought that OX-40 expression was restricted to activated conventional T cells, it has now been visualized on activated regulatory T cells, NKT cells, NK cells, and neutrophils. OX-40 plays a major role in regulating both CD4 and CD8 T cell clonal expansion. It provides a costimulatory signal to an antigen-reacting naive T cells to prolong proliferation, as well as augment the production of several cytokines. This is demonstrated by OX-40 knockout mice which generate fewer primary effector CD4 T cells after immunization. Furthermore, in vivo treatment with an agonist antibody to OX-40 has been shown to strongly enhance the generation of antigen-specific effector T cells and prevent the induction of T cell tolerance. The OX-86 antibody is an agonistic antibody that has been shown to delay tumor growth in vivo.
- Format:
- Purified
- Gendetails:
- Tnfrsf4
- Host:
- Rat
- Immunogen:
- Recombinant mouse OX40-CD4 chimeric protein
- Isotyp:
- Rat IgG1, kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- The antibody solution should be stored undiluted at 4[o]C; and protected from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php