Monoclonal Antibody to HGAL (Clone: ABM43E6)
Produktgrößen
25ug
£319,00
10-7544-25UG
100ug
£429,00
10-7544-100UG
Über dieses Produkt
- SKU:
- 10-7544
- Zusätzliche Namen:
- GCSAM||GAL||GCET2
- translate.label.attr.clone:
- ABM43E6
- Klonalität:
- Monoclonal
- Weitere Details:
- Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1). HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.
- Format:
- Purified
- Gendetails:
- GCSAM
- Host:
- Mouse
- Immunogen:
- A full length human HGAL protein was used as the immunogen for this antibody
- Isotyp:
- Mouse IgG1 Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg