Skip to content

Warenkorb

Der Warenkorb ist leer.

Gesamt (exkl. MwSt.) £0,00
Warenkorb überprüfen & bezahlen
Antikörper

Monoclonal Antibody to MBD2/MBD3 (Clone: ABM14A8)

Produktgrößen
25ug
£319,00
10-7006-25UG
100ug
£429,00
10-7006-100UG
Über dieses Produkt
SKU:
10-7006
Zusätzliche Namen:
MBD3
translate.label.attr.clone:
ABM14A8
Klonalität:
Monoclonal
Weitere Details:
MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. This protein binds around 1 kb downstream of the transcription start site of a subset of  400 CpG island promoters that are characterized by the presence of active histone marks, RNA polymerase II (Pol2) and low to medium gene expression levels and H3K36me3 deposition. Methylated MBD2 is involved in silencing methylated tumor suppressor genes as well as activation of pro-metastatic genes. MBD2 also plays a key role in regulating expression of a range of genes that are associated with optimal DC (Dendritic cells) activation and function.
Format:
Purified
Gendetails:
MBD3
Host:
Mouse
Immunogen:
A partial length recombinant MBD3 protein (amino acids 1-290) was used as the immunogen for this antibody.
Isotyp:
Mouse IgG1 Kappa
Aufreinigung:
Protein G Chromatography
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig-2 : Immunohistochemical analysis of MBD3 in human breast tissue using MBD3 antibody (Clone: ABM14A8) at 5 µg/ml.
Fig-3 : Immunohistochemical analysis of MBD3 in human Kidney tissue using MBD3 antibody (Clone: ABM14A8) at 10 µg/ml.
Fig-4 : Immunohistochemical analysis of MBD3 in human Testis tissue using MBD3 antibody (Clone: ABM14A8) at 10 µg/ml.
Fig-4 : Immunohistochemical analysis of MBD3 in human Testis tissue using MBD3 antibody (Clone: ABM14A8) at 10 µg/ml.
Fig-5: Intracellular flow analysis of MBD2/MBD3 in Jurkat cells using 0.5 µg/10^6 cells of MBD2/MBD3 antibody (Clone: ABM14A8). Green represents isotype control; red represents anti-MBD2/MBD3 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.