Monoclonal Antibody to Ikke/Ikki/TBK1 (Clone: ABM13C7)
Produktgrößen
25ug
£319,00
10-6015-25UG
100ug
£429,00
10-6015-100UG
Über dieses Produkt
- SKU:
- 10-6015
- Zusätzliche Namen:
- IKBKE||IKKE||IKKI||KIAA0151
- translate.label.attr.clone:
- ABM13C7
- Klonalität:
- Monoclonal
- Weitere Details:
- Ikke is a member of the IKK (IKappaB kinase) family that has been identified as an oncogenic protein and found to be up-regulated in breast cancer, ovarian cancer and prostate cancer. The Ikke protein has 33% and 31% identity at the amino acid level with Ikka and Ikkb, respectively and is primarily activated by interferon and mediates interferon signaling. The activated Ikke stimulates the transcription factor interferon regulatory factors 3 and phosphorylates signal transducer and activator of transcription. Ikke also shares some function with Ikka and Ikkb to activate NF- KappaB pathway by phosphorylation and degradation of IKappaBalpha. However, Ikke mainly mediates NF-KappaB activation induced by interferon, phorbol 12-myristate 13-acetate or the T-cell receptor, but not by tumor necrosis factor and interleukin 1, which activate Ikka and Ikkb. Ikke is predominantly expressed and active in peripheral blood leukocytes, pancreas, thymus, and spleen and contributes to IRF as well as NF-KappaB activation.
- Format:
- Purified
- Gendetails:
- IKBKE
- Host:
- Mouse
- Immunogen:
- A partial length recombinant Ikke protein (amino acids 2-203) was used as the immunogen for this antibody.
- Isotyp:
- Mouse IgG2a Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
