Monoclonal Antibody to CD28 (Clone: CB28)
Produktgrößen
25ug
£319,00
10-4137-25UG
100ug
£375,00
10-4137-100UG
Über dieses Produkt
- SKU:
- 10-4137
- Zusätzliche Namen:
- T-cell-specific surface glycoprotein CD28; TP44; CD28
- translate.label.attr.clone:
- CB28
- Klonalität:
- Monoclonal
- Weitere Details:
- CD28 is a type I transmembrane protein that binds through its extracellular region to B7 proteins (CD80 and CD86), which are transmembrane proteins expressed on the surface of APCs (Antigen-Presenting Cells) and are up-regulated by inflammatory signals. CD28 mediates signals that promote T lymphocyte differentiation and proliferation, and enhance antibody production of B lymphocytes. Deficiencies in CD28 pathways result in complete T lymphocyte tolerance in vitro and in vivo. Both CD4+ and CD8+ memory T cells need CD28 costimulation to achieve maximal expansion and pathogen clearance. The blockade of the CD28-B7 interaction has been used to down-regulate the activation of the immune system in autoimmune diseases. Based on the expression of the costimulatory molecule CD28 on the surface of CD8+ T cells, two different lymphocyte subgroups have been designated: antigen-primed cytotoxic T cells (CD8+CD28+ T cells) and suppressor T cells (CD8+CD28ˆ’ T cells). The frequency of CD28+CD8+T cells and especially the balance between CD8+CD28+ and CD8+CD28ˆ’ T cells are important in many diseases, including CHB (Chronic Hepatitis B).
- Format:
- Purified
- Gendetails:
- CD28
- Host:
- Mouse
- Immunogen:
- A partial length recombinant protein from CD28 was used as the immunogen for this antibody.
- Isotyp:
- Mouse IgG1, Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
