Monoclonal Antibody to RIG-I (Clone: ABM4H29)
Produktgrößen
25ug
£319,00
10-4121-25UG
100ug
£429,00
10-4121-100UG
Über dieses Produkt
- SKU:
- 10-4121
- Zusätzliche Namen:
- DDX58
- translate.label.attr.clone:
- ABM4H29
- Klonalität:
- Monoclonal
- Weitere Details:
- RIG-I (retinoic-acid-inducible gene I), also known as DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) is a 925-residue cytoplasmic viral RNA receptor, critically involved in the activation of the innate immune response to RNA virus infection. It is a member of the RIG-I-like receptor (RLR) family and is an essential intracellular sensor for several 5-triphosphorylated RNA viruses. RIG-I elicits its antiviral interferon (IFN) responses by recognizing viral double-stranded RNAs (dsRNAs). Structurally it comprises a helicase domain, a C-terminal domain, and N-terminal CARDs (caspase activation recruitment domains) involved in activating MAVS (mitochondrial antiviral signaling protein). Upon binding of 5'-triphosphorylated RNA, RIG-I undergoes conformational changes and post-translational modifications that allow multimerization and interaction with the mitochondrial antiviral signaling protein (MAVS).
- Format:
- Purified
- Gendetails:
- DDX58
- Host:
- Mouse
- Immunogen:
- A partial length recombinant human RIG-I protein (amino acids 1-220) was used as the immunogen for this antibody.
- Isotyp:
- Mouse IgG1 Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
