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Antikörper

Monoclonal Antibody to CLEC4E (Clone: ABM42C6)

Produktgrößen
25ug
£319,00
10-4120-25UG
100ug
£429,00
10-4120-100UG
Über dieses Produkt
SKU:
10-4120
Zusätzliche Namen:
CLEC4E||CLECSF9||MINCLE||UNQ218/PRO244
translate.label.attr.clone:
ABM42C6
Klonalität:
Monoclonal
Weitere Details:
CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor that specifically binds to the cord factor TDM (trehalose-6,6-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells. CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in inflammation.
Format:
Purified
Gendetails:
CLEC4E
Host:
Mouse
Immunogen:
A full length human CLEC4E protein was used as the immunogen for this antibody.
Isotyp:
Mouse IgG1 Kappa
Aufreinigung:
Protein G Chromatography
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Figure-2: cell surface flowcytometric analysis of Anti-CLEC4E in A431 cells using 0.5 µg/10^6 cells of Anti-CLEC4E (clone: ABM42C6) . Green represent isotype control and red represent Anti-CLEC4E antibody (10-4120 ABEOMICS). Goat anti-mouse PE conjugate was used as the secondary antibody.
Figure-3: cell surface flowcytometric analysis of Anti-CLEC4E in HeLa cells using 0.5 µg/10^6 cells of Anti-CLEC4E (clone: ABM42C6) . Green represent isotype control and red represent Anti-CLEC4E antibody (10-4120 ABEOMICS). Goat anti-mouse PE conjugate was used as the secondary antibody.
Figure-3: cell surface flowcytometric analysis of Anti-CLEC4E in HeLa cells using 0.5 µg/10^6 cells of Anti-CLEC4E (clone: ABM42C6) . Green represent isotype control and red represent Anti-CLEC4E antibody (10-4120 ABEOMICS). Goat anti-mouse PE conjugate was used as the secondary antibody.