Monoclonal Antibody to IL-23R (Clone: ABM25G4)
Produktgrößen
25ug
£319,00
10-4030-25UG
100ug
£429,00
10-4030-100UG
Über dieses Produkt
- SKU:
- 10-4030
- Zusätzliche Namen:
- Interleukin-23 receptor; IL-23 receptor; IL-23R
- translate.label.attr.clone:
- ABM25G4
- Klonalität:
- Monoclonal
- Weitere Details:
- IL-23, a member of the IL-12 cytokine family, is composed of a p40 subunit, which is shared with IL-12, and a p19 subunit, with an approximate molecular weight of 60 kDa. IL-23 is produced by activated dendritic cells and macrophages in response to microorganisms. IL-23 promotes Th17 cells producing TNF-a, IL-17, IL-6, IL-22, GM-CSF, and other novel factors, which are associated with the induction of autoimmune inflammation. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.
- Format:
- Purified
- Gendetails:
- IL23R
- Host:
- Mouse
- Immunogen:
- A partial length recombinant protein (a.a 250-450) of IL-23R was used as the immunogen for this antibody.
- Isotyp:
- Mouse IgG1, Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
