Monoclonal antibody to MyD88 (Clone: ABM2H20) FITC Conjugated
Produktgrößen
25ug
£319,00
10-3012-F-25UG
100ug
£429,00
10-3012-F-100UG
Über dieses Produkt
- SKU:
- 10-3012-F
- translate.label.attr.clone:
- ABM2H20
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway.
- Format:
- Purified
- Gendetails:
- MYD88
- Host:
- Mouse
- Immunogen:
- A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody.
- Isotyp:
- Mouse IgG1 Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:10-3012-F.jpg