Monoclonal Antibody to TLR3 (Clone: ABM15D5)-FITC conjugated
Produktgrößen
25ug
£319,00
10-3004-F-25UG
100ug
£429,00
10-3004-F-100UG
Über dieses Produkt
- SKU:
- 10-3004-F
- Zusätzliche Namen:
- TLR3
- translate.label.attr.clone:
- ABM15D5
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.
- Format:
- Purified
- Gendetails:
- TLR3
- Host:
- Mouse
- Immunogen:
- A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.
- Isotyp:
- Mouse IgG1 Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:THP1.jpg