Monoclonal Antibody to p53 (Clone BP53-12)
Produktgrößen
100ug
£429,00
10-1053-100UG
Über dieses Produkt
- SKU:
- 10-1053
- Zusätzliche Namen:
- TP53||P53
- translate.label.attr.clone:
- BP53-12
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
- Format:
- Purified
- Gendetails:
- TP53
- Host:
- Mouse
- Immunogen:
- Recombinant human wild-type p53 protein was used as immunogen.
- Isotyp:
- Mouse IgG2a Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
