Monoclonal Antibody to Bcl-2 (Clone: BC1)
Produktgrößen
25ug
£319,00
10-1052-25UG
100ug
£429,00
10-1052-100UG
Über dieses Produkt
- SKU:
- 10-1052
- Zusätzliche Namen:
- BCL2
- translate.label.attr.clone:
- BC1
- Klonalität:
- Monoclonal
- Weitere Details:
- Bcl-2 (B-cell lymphoma 2), is a member of Bcl-2 family of regulator proteins. These proteins contain a hydrophobic cleft that binds to BH3-only proteins and to the pro-apoptotic Bcl-2 family members Bad, Bak, and Bax to inhibit apoptosis. In the absence of this binding, the proapoptotic Bcl-2 members are recruited to the OMM (Outer Mitochondrial Membrane) at which they oligomerize and cause OMM permeabilization, releasing proapoptotic effectors such as SMAC or cytochrome-c. Bcl-2 also neutralize a group of 'sensor' proteins (such as BIM), which are triggered by cytotoxic stimuli such as chemotherapy. BCL-2 proteins therefore have a central role as guardians against apoptosis, helping cancer cells to evade cell death.
- Format:
- Purified
- Gendetails:
- BCL2
- Host:
- Mouse
- Immunogen:
- A synthetic peptide corresponding to amino acids 41-54 (GAAPAPGIFSSQPG-Cys); of human Bcl-2 was used as immunogen.
- Isotyp:
- Mouse IgG1 Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
