Monoclonal antibody to Bi-1 (Clone: ABM20E4)
Produktgrößen
25ug
£319,00
10-1044-25UG
100ug
£429,00
10-1044-100UG
Über dieses Produkt
- SKU:
- 10-1044
- Zusätzliche Namen:
- TMBIM6||BI1||TEGT
- translate.label.attr.clone:
- ABM20E4
- Klonalität:
- Monoclonal
- Weitere Details:
- Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased; however, up-regulated expression of this protein has been linked to increased cell proliferations.
- Format:
- Purified
- Gendetails:
- TMBIM6
- Host:
- Mouse
- Immunogen:
- A partial length recombinant protein of human Bi-1 (amino acids 1-200) was used as an immunogen for this antibody.
- Isotyp:
- Mouse IgG2a Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg