Monoclonal Antibody to ATF6 (Clone: ABM1A40)
Produktgrößen
25ug
£319,00
10-1018-25UG
100ug
£429,00
10-1018-100UG
Über dieses Produkt
- SKU:
- 10-1018
- Zusätzliche Namen:
- ATF6
- translate.label.attr.clone:
- ABM1A40
- Klonalität:
- Monoclonal
- Weitere Details:
- ATF6, also named as Cyclic AMP-dependent transcription factor ATF-6 alpha is a member of bZIP family, ATF subfamily. ATF6 forms homodimer and heterodimer with ATF6-beta. ATF6 acts by activating specific unfolded protein response target genes during endoplasmic reticulum stress. ATF6 is a ubiquitously expressed transcription factor located at endoplasmic reticulum (ER) membrane. During ER stress an approximately 50 kDa fragment containing the N-terminal cytoplasmic domain is cleaved by proteolysis and is translocated into the nucleus. N-glycosylation may serve as a sensor for ER homeostasis. For the binding of ATF6 to ERSE, ESRE should first bind to another transcription factor called Nuclear Transcription Factor Y (NF-Y). ATF6 could also be involved in activation of transcription by interacting with serum response factor. ATF6 is a 74 kDa protein and is highly expressed in kidney, liver, colon and mammary gland.
- Format:
- Purified
- Gendetails:
- ATF6
- Host:
- Mouse
- Immunogen:
- A partial length recombinant ATF6 protein (amino acids 1-400) was used as the immunogen for this antibody.
- Isotyp:
- Mouse IgG1 Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
