Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12) FITC Conjugated
Produktgrößen
100ug
£429,00
10-1003-F-100UG
Über dieses Produkt
- SKU:
- 10-1003-F
- Zusätzliche Namen:
- Casp3; Cpp32
- translate.label.attr.clone:
- ABM1C12
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Weitere Details:
- Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.
- Format:
- Purified
- Gendetails:
- CASP3
- Host:
- Mouse
- Immunogen:
- Full length recombinant Caspase-3 protein was used as the immunogen for this antibody.
- Isotyp:
- Mouse IgG1 Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:10-1003-F.jpg