Monoclonal Antibody to Dc-Sign/CD 209 (Clone: ABM47B7)
Produktgrößen
25ug
£319,00
10-10020-25UG
100ug
£429,00
10-10020-100UG
Über dieses Produkt
- SKU:
- 10-10020
- Zusätzliche Namen:
- CD209||CLEC4L
- translate.label.attr.clone:
- ABM47B7
- Klonalität:
- Monoclonal
- Weitere Details:
- Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a tetrameric C-type (calcium-dependent) lectin that binds, through its C-terminal carbohydrate recognition domain, high mannose N-linked glycans present on the surface of several viral glycoproteins such as human immunodeficiency virus (HIV) gp120 and hepatitis C virus (HCV) E2. It facilitates DC-specific delivery of Ag. This is accomplished by conjugating Ag to receptor-specific Ab or carbohydrate ligands that bind to its carbohydrate recognition domain. In humans, DC-SIGN expression is restricted to DCs and certain types of macrophages. DC-SIGN is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens, including viruses, bacteria, fungi, and parasites. After binding, these pathogens are internalized and pathogen-derived antigens are presented via MHC class I and II molecules to CD8+ and CD4+ T cells, respectively. DC-SIGN represents a promising CLR for targeted vaccine delivery.
- Format:
- Purified
- Gendetails:
- CD209
- Host:
- Mouse
- Immunogen:
- A recombinant protein fragment of DC-Sign protein was used as the immunogen for this antibody.
- Isotyp:
- Mouse IgG2b Kappa
- Aufreinigung:
- Protein G Chromatography
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
