Recombinant Human SLAMF3/LY9/CD229 Protein
Produktgrößen
10 ug
£145,00
RP02165-10UG
50 ug
£288,00
RP02165-50UG
500 ug
£1478,00
RP02165-500UG
1000 ug
£1954,00
RP02165-1000UG
Über dieses Produkt
- SKU:
- RP02165
- Zusätzliche Namen:
- LY9,CD229,SLAMF3,hly9,mLY9
- Weitere Details:
- SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains. The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3. Within the first two Ig-like domains that are common to all SLAM proteins, human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, NTB-A, and SLAM. It is expressed on T and B cells, thymocytes, and more weakly on NK cells. It may participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. SLAMF3 may be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. It also disable autoantibody responses and inhibit IFN-gamma secretion by CD4+ T-cells and negatively regulate the size of thymic innate CD8+ T-cells and the development of invariant natural killer T (iNKT) cells.
- Formulierung:
- Recombinant Human SLAMF3/LY9/CD229 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Lys48-Lys454) of human SLAMF3 (Accession #Q9HBG7) fused with a 6xH
- Immunogen:
- Lys48-Lys454
- Molekulargewicht:
- 75 kDa
- Physischer Zustand:
- Lyophilized
- Reinheit:
- ≥95%
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:RP02165