Recombinant Human IFN-alpha I/IFN17 Protein
Produktgrößen
10 ug
£145,00
RP01899-10UG
20 ug
£193,00
RP01899-20UG
50 ug
£288,00
RP01899-50UG
500 ug
£1240,00
RP01899-500UG
1000 ug
£1954,00
RP01899-1000UG
Über dieses Produkt
- SKU:
- RP01899
- Zusätzliche Namen:
- Interferon alpha-17, IFN-alpha-17, Interferon alpha-88, Interferon alpha-I', LeIF I, Interferon alpha-T, IFNA17
- Weitere Details:
- Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors . Human IFNA2 was originally cloned in the early '80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology . Structurally, type I IFNs belong to the class of five helicalbundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds . There is not a mouse homolog for IFNA17, but mature human IFNA17 shares 58% aa sequence identity with chimpanzee IFNA17. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit) . Individual IFNA subtypes are known to display unique efficacies to viral protection . IFNA17 has been shown to be potent against HIV-1 activity . Human IFNA17 is the only IFNA subtype identified with antiviral activity but a reduced ability to activate NK cells . A mutation in IFNA17, Ile184Arg, is associated with an increased risk for cervical cancer.
- Formulierung:
- Recombinant Human IFN-alpha I/IFN17 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys24-Asp189) of Human IFN-alpha I/IFN17 (Accession #NP_067091
- Immunogen:
- Cys24-Asp189
- Molekulargewicht:
- 20-25 kDa
- Physischer Zustand:
- Lyophilized
- Reinheit:
- ≥95%
- Sequenz:
- CDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFGLPQEEFDGNQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNNLEACVIQEVGMEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKILRRKD
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:RP01899