Recombinant Mouse IGF-II Protein
Produktgrößen
10 ug
£127,00
RP01881-10UG
20 ug
£157,00
RP01881-20UG
50 ug
£223,00
RP01881-50UG
100 ug
£336,00
RP01881-100UG
500 ug
£907,00
RP01881-500UG
1000 ug
£1478,00
RP01881-1000UG
Über dieses Produkt
- SKU:
- RP01881
- Zusätzliche Namen:
- C11orf43|chromosome 11 open reading frame 43|FLJ22066|FLJ44734|GRDF|IGF-2|IGF-II|IGF2|IGFII|insulin-like growth factor 2 (somatomedin A)|insulin-like growth factor II|insulin-like growth factor type 2|MSA|PEG2|PP9974|somatomedin-A
- Weitere Details:
- IGF-II (Insulin-like growth factor II; also multiplication-stimulating polypeptide/MSP and somatomedin-A) is a secreted 8 kDa polypeptide that belongs to the insulin family of peptide growth factors. It is part of a complex system of growth and metabolic-regulating proteins that is particularly important during development. It has been associated with nervous system proliferation and differentiation, myelination, adrenal cortical proliferation, and skeletal growth and differentiation . In human, IGF-II is primarily synthesized by the liver, and circulates at high levels in both fetus and adult. In rodent, however, IGF-II levels drop after the perinatal period, an effect attributed to the lack of a key gene promoter . This may indicate that postnatally, IGF-II has either a limited, or local effect only in rodent. For example, evidence suggests IGF-II may be the intermediary for SHH induction of VEGF attendant with local neovascularization . Rodent cells known to express IGF-II include astrocytes , hepatocytes , osteoblasts , embryonic striated muscle cells plus Kupffer cells and Ito cells . Mouse IGF-II is synthesized as a 180 amino acid (aa) preproprecursor). It contains a 24 aa signal sequence, a 67 aa mature region, and an 89 aa C-terminal prodomain that is alternatively referred to as the E-peptide. Mature IGF-II is 91% and 97% aa identical to human and rat IGF-II, respectively. Proper processing of IGF-II requires the chaperone activity of GRP94 . This generates an 8 kDa mature form, an 18 kDa, 156 aa proform, and a potential 11 kDa, 88 aa "Big" form (aa 25-112). This 11 kDa "Big" form would be equivalent to human 15-16 kDa IGF-II, with the 5 kDa difference attributable to the presence of O-linked glycosylation . There is an additional 34 aa proteolytic fragment that is termed preptin and contains aa 93-126 of the preproprecursor. This is distinct from IGF-II, is secreted by pancreatic b cells, and facilitates insulin secretion. IGF-II has multiple binding partners. It binds to IGF-IR, the Insulin receptor (IR)-type A and IGF-IR:IR-A hybrids, the type 2 IGF receptor (IGF-2R), and IGF binding proteins 1-6 . The first three receptors initiate downstream signaling events, the IGF-2R sequesters local IGF-II, and the six IGFBPs regulate IGF-II activity in various tissues.
- Formulierung:
- Recombinant Mouse IGF-II Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala25-Glu91) of Mouse IGF-II (Accession #NP_001116208.1) fused with a hFc
- Immunogen:
- Ala25-Glu91
- Molekulargewicht:
- 35-45kDa
- Physischer Zustand:
- Lyophilized
- Reinheit:
- ≥95%
- Sequenz:
- AYGPGETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSE
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:RP01881