Recombinant Human HMGB1-EGFP Protein
Produktgrößen
10 ug
£145,00
RP01737-10UG
20 ug
£193,00
RP01737-20UG
50 ug
£288,00
RP01737-50UG
100 ug
£431,00
RP01737-100UG
500 ug
£1240,00
RP01737-500UG
1000 ug
£1954,00
RP01737-1000UG
Über dieses Produkt
- SKU:
- RP01737
- Zusätzliche Namen:
- HMG-1|HMG1|HMG3|HMGB1-EGFP|SBP-1
- Weitere Details:
- High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, released actively following cytokine stimulation as well as passively during cell death. It is the prototypic damage-associated molecular pattern (DAMP) molecule and has been implicated in several inflammatory disorders. As a non-histone nuclear protein, HMGB1 has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription, and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. Extracellular HMGB1 represents an optimal " necrotic marker" selected by the innate immune system to recognize tissue damage and initiate reparative responses. However, extracellular HMGB1 also acts as a potent pro-inflammatory cytokine that contributes to the pathogenesis of diverse inflammatory and infectious disorders. HMGB1 has been successfully therapeutically targeted in multiple preclinical models of infectious and sterile diseases including arthritis. As shown in studies on patients as well as animal models, HMGB1 can play an important role in the pathogenesis of the rheumatic disease, including rheumatoid arthritis, systemic lupus erythematosus, and polymyositis among others. Besides, enhanced postmyocardial infarction remodeling in type 1 diabetes mellitus was partially mediated by HMGB1 activation.
- Formulierung:
- Recombinant Human HMGB1-EGFP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence ((Met1-Glu215)& (GGGS) 3&EGFP) of human HMGB1-EGFP (Accession #NP_0021
- Immunogen:
- (Met1-Glu215)& (GGGS) 3&EGFP
- Molekulargewicht:
- 60 kDa kDa
- Physischer Zustand:
- Lyophilized
- Reinheit:
- ≥95%
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:RP01737