Recombinant Human IFNAR1 Protein
Produktgrößen
10 ug
£127,00
RP01511-10UG
20 ug
£175,00
RP01511-20UG
50 ug
£240,00
RP01511-50UG
100 ug
£336,00
RP01511-100UG
500 ug
£1002,00
RP01511-500UG
1000 ug
£1574,00
RP01511-1000UG
Über dieses Produkt
- SKU:
- RP01511
- Zusätzliche Namen:
- AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC,IFNAR1,IFN-alpha-REC,IFNAR,IFNBR,IFRC
- Weitere Details:
- Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
- Formulierung:
- Recombinant Human IFNAR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys28-Lys436) of human IFN-alpha/beta R1 (Accession #NP_000620.2) fused w
- Immunogen:
- Lys28-Lys436
- Molekulargewicht:
- 80-90 kda
- Physischer Zustand:
- Lyophilized
- Reinheit:
- ≥95%
- Sequenz:
- KNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSK
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:RP01511