Recombinant Human SIRP-beta 1/CD172b Protein
Produktgrößen
10 ug
£133,00
RP01351-10UG
20 ug
£181,00
RP01351-20UG
50 ug
£240,00
RP01351-50UG
100 ug
£353,00
RP01351-100UG
500 ug
£1002,00
RP01351-500UG
1000 ug
£1574,00
RP01351-1000UG
Über dieses Produkt
- SKU:
- RP01351
- Zusätzliche Namen:
- 9930027N05Rik,SIRP-beta,Sirpb,Sirpb1,SIRPB1
- Weitere Details:
- Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRP1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily.Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.
- Formulierung:
- Recombinant Human SIRP-beta 1/CD172b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu30-Leu371) of human SIRPB1/CD172b (Accession #NP_006056.2)
- Immunogen:
- Glu30-Leu371
- Molekulargewicht:
- 55-60 kDa
- Physischer Zustand:
- Lyophilized
- Reinheit:
- ≥95%
- Sequenz:
- EDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:RP01351