Recombinant Human IFNAR2 Protein
Produktgrößen
10 ug
£133,00
RP01342-10UG
20 ug
£181,00
RP01342-20UG
50 ug
£240,00
RP01342-50UG
100 ug
£353,00
RP01342-100UG
500 ug
£1002,00
RP01342-500UG
1000 ug
£1574,00
RP01342-1000UG
Über dieses Produkt
- SKU:
- RP01342
- Zusätzliche Namen:
- IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha/beta receptor 2,IFN-R,IFN-alpha-REC,IFNABR,IFNARB,IMD45
- Weitere Details:
- Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family.Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNA Alpha therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNA Alpha therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2, and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNA Alpha2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNB Beta, it recycles back to the cell surface.
- Formulierung:
- Recombinant Human IFNAR2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile27-Lys243) of human IFNAR2/IFNARB (Accession #NP_997468.1) fused with
- Immunogen:
- Ile27-Lys243
- Molekulargewicht:
- Approximately 70 kDa
- Physischer Zustand:
- Lyophilized
- Reinheit:
- ≥95%
- Sequenz:
- ISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAK
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:RP01342
