Recombinant Human Alpha-2-macroglobulin/A2M Protein
Produktgrößen
10 ug
£122,00
RP00785-10UG
20 ug
£223,00
RP00785-20UG
50 ug
£253,00
RP00785-50UG
100 ug
£509,00
RP00785-100UG
500 ug
£1478,00
RP00785-500UG
1000 ug
£2335,00
RP00785-1000UG
Über dieses Produkt
- SKU:
- RP00785
- Zusätzliche Namen:
- A2M, Alpha-2-macroglobulin, Alpha-2-M, CPAMD5
- Weitere Details:
- alpha-2-macroglobulin, also known as A Alpha2-macroglobulin (A Alpha2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells. In addition to this function as an agent for protease clearance, alpha2-macroglobulin binds a variety of other ligands, including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods.
- Formulierung:
- Recombinant Human Alpha-2-macroglobulin/A2M Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Ala1474) of Human Alpha-2-macroglobulin/A2M (Acc
- Immunogen:
- Ser24-Ala1474
- Reinheit:
- >95%
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Datenblatt des Herstellers:RP00785
