ABflo[R] 450 Rabbit anti-Human CD152/CTLA-4 monoclonal antibody
Produktgrößen
10 tests
£ POA
A26550-10TESTS
100 tests
£384,00
A26550-100TESTS
2 x 100 tests
£610,00
A26550-2X100TESTS
5 x 100 tests
£1074,00
A26550-5X100TESTS
Über dieses Produkt
- SKU:
- A26550
- Zusätzliche Namen:
- ALPS5|CD|CD152|CELIAC3|CTLA-4|GRD4|GSE|IDDM12
- Anwendung:
- Flow Cytometry
- Klonalität:
- Monoclonal
- Konjugat:
- ABflo™ 450
- Weitere Details:
- Cytotoxic T-lymphocyte protein 4 (CTLA-4, CD152) is a member of the immunoglobulin superfamily that negatively regulates early T-cell activation. This protein is primarily expressed on T cells, including CD8+ cytotoxic T cells, CD4+ helper T cells, and CD4+/FoxP3+ regulatory T cells (Tregs). On the cell surface, CTLA-4 competes with CD28 for binding to the ligands B7.1 (CD80) and B7.2 (CD86), thereby downregulating T-cell activity. The subsequent activation of downstream effectors SHP-2 and PP2A attenuates TCR signaling. Studies have shown that CTLA-4 gene knockout mice develop severe lymphoproliferative disorders and die at an early age, confirming the essential role of CTLA-4 as a negative regulator of T cells. Correspondingly, mutations in the CTLA4 gene are associated with various autoimmune and immune dysregulation syndromes, including insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, and autoimmune lymphoproliferative syndrome type V. Further research has established that blockade of the CTLA-4 pathway represents an effective strategy in cancer immunotherapy.
- Formulierung:
- Unmodified
- Host:
- Rabbit
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotyp:
- IgG
- Molekulargewicht:
- 25kDa
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:A26550