[KO Validated] MLH1 Mouse monoclonal antibody
Produktgrößen
5 ul
£ POA
A21882-5UL
20 ul
£164,00
A21882-20UL
100 ug
£342,00
A21882-100UG
500 ul
£1532,00
A21882-500UL
1000 ul
£2704,00
A21882-1000UL
Über dieses Produkt
- SKU:
- A21882
- Zusätzliche Namen:
- COCA2|FCC2|H1|hMLH1|HNPCC|HNPCC2|LYNCH2|MLH-1|MMRCS1
- Anwendung:
- ELISA, Western Blot
- Klonalität:
- Monoclonal
- Weitere Details:
- The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
- Formulierung:
- Unmodified
- Host:
- Mouse
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Isotyp:
- IgG1, kappa
- Molekulargewicht:
- Refer to figures
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- ABclonal Technology
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:A21882