Ubiquitin

Ubiquitin touches all aspects of cell biology.  Any textbook will tell you that ubiquitin marks proteins for degradation, but there is so much more to the ubiquitin pathway than degradation.  These lesser known and important functions are now being uncovered.

Ubiquitin is conjugated to proteins in many different formations and these formations determine the cellular fate of a protein.  Both mono-ubiquitylation and poly-ubiquitylation occur for separate reasons.  There are 8 different types of poly-ubiquitin chains that can exist via isopeptide bonds between K6, K11, K27, K29, K33, K48, K63, or M1.

Ubiquitin Labelled Lysines

Recent publications in large fields (e.g. GPCRs, RTKs, cell cycle, immunology, etc.) are illustrating the importance of ubiquitin in clinically important pathways.  For example, the balance between receptor recycling and degradation - and thus, the prescence of your drug target - is controlled by ubiquitin.

 

LifeSensors is helping to unravel the ubiquitin code by providing researchers with innovative tools and ideas to interrogate the pathway. The full list of LifeSensors products can be found through this link.