Why collagen is the best matrix to grow cells?
Collagen is a very important extracellular matrix protein for biological structures. It can accurately mimic the in vivo micro-environment to develop high-quality cells for a wide variety of applications.
Choosing the correct matrix for your cells can help you achieve improved results in the lab, as not every collagen is equal.
With expert opinion throughout, our new whitepaper: 'Collagen in the Lab' aims to explain why collagen is still and will always be the best matrix to grow cells.
- What cells need to grow and some of the challenges researchers face
- The importance of collagen
- Collagen sources
- The future of collagen in cell culture and regenerative medicine
You can download the whitepaper for free here and we hope you will find it valuable and insightful.
Collagen is the most abundant protein in mammals and is found in skin, cartilage, bone, intervertebral discus, blood vessels, tendons, ligaments, cornea and is a key protein component of the Extra Cellular Matrix (ECM). Collagen is therefore regarded as the building block of tissue. Fibrillar collagens in particular are the more abundant extracellular proteins. They form a metazoan-specific family, and are highly conserved from sponge to human.
For many decades, collagen extracted from mammalian (pigs, cows, sheep) have been successfully used in the food, cosmetic, medical device and pharmaceutical industries. However due to rising safety concerns around use of mammalian derived products (viral disease vectors and BSE), safer alternatives are being sought. Jellyfish offer that safer and disease-free alternative.
Jellyfish first evolved on earth some 600 million years ago and are often referred to as Gelatinous Zooplankton. They are abundant in supply and an evolutionary ancient form of collagen. Jellagen is pioneering the manufacture and development of a next generation collagen for the use in medical device.
Jellyfish collagen is an evolutionary ancient chemical template and is where all collagens up the tree of life have been derived. Jellyfish collagen is in essence, the root of all collagens, compatible with a broad range of cell types making it an ideal biomaterial for medical devices.
The value proposition of the company is based on the unique selling features of jellyfish collagen scaffolds which are:
- Evolutionary ancient chemistry offering a next generation collagen biomaterial able to provide distinctive functional advantages over mammalian collagens.
- Lower immunogenicity than mammalian sourced materials allowing for the potential of transferring direct in vivo analytical results into in vivo applications, providing a significant opportunity for accuracy in clinical development.
- Batch to batch product consistency compared to mammalian collagen.
- A disease vector (BSE) free collagen
Jellagen believes that its next generation jellyfish derived collagen can address all the existing collagen market today with its unique positioning and comparable cost.