COVID-19 Schematic

Further information

	Various steps in the stages of COVID-19
	Entry of Virus ⇒	⇒ Viral Replication ⇒		⇒ Immune Response⇒		⇒ Acute Respiratory Distress Syndrome
Targets involved in each step	ACE2	Lectins	TLRs	C3	IL-1
				C5	IL-6
				CCL2	IL-8
				IFN	IL-21
				Macrophages	TNF

Host pathway in proteome interaction screen	Corresponding SARS-CoV-2 proteins interacting with host pathway
DNA replication	Nsp1
Epigenetic and gene expression regulators	Nsp5, Nsp8, Nsp13
Vesicle trafficking	Nsp6, Nsp7, Nsp10, Nsp13, Nsp15, Orf3a, Orf8
Lipid modification	Spike
RNA processing and regulation	Nsp8
Ubiquitin ligases	Orf10
Host signaling	Nsp8, Nsp13, Orf9b
Nuclear transport machinery	Nsp9, Nsp15, Orf6
Cytoskeleton	Nsp1, Nsp13
Mitochondria	Nsp4, Nsp8, Orf9c
Extracellular matrix	Nsp9

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