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COVID-19 Schematic

Further information

  Various  steps in the stages of COVID-19
Entry of Virus ⇒ ⇒ Viral Replication ⇒ ⇒ Immune Response⇒ ⇒ Acute Respiratory Distress Syndrome
Targets involved in each step ACE2 Lectins TLRs C3 IL-1
C5 IL-6
Macrophages TNF
Host pathway in proteome interaction screen Corresponding SARS-CoV-2 proteins interacting with host pathway
DNA replication Nsp1
Epigenetic and gene expression regulators Nsp5, Nsp8, Nsp13
Vesicle trafficking Nsp6, Nsp7, Nsp10, Nsp13, Nsp15, Orf3a, Orf8
Lipid modification Spike
RNA processing and regulation Nsp8
Ubiquitin ligases Orf10
Host signaling Nsp8, Nsp13, Orf9b
Nuclear transport machinery Nsp9, Nsp15, Orf6
Cytoskeleton Nsp1, Nsp13
Mitochondria Nsp4, Nsp8, Orf9c
Extracellular matrix Nsp9