Highly Active Human Interferon Proteins
High quality recombinant proteins derived from bacterial or mammalian cells
- Consistent performance and biological activity
- 95% or greater purity
- Endotoxin level < 1 EU/μg
- Suitable for use in a range of applications including ELISAs & cytopathic effect assays
Featured:
Universal Type I Interferon (Cat. No. 11200)
Unique hybrid interferon exhibiting activity across multiple species
- Useful for cross-species comparative studies of Type I IFN effects
- Broad crossover to multiple animal models in vivo and in vitro where the species relevant Type I IFN-α is unavailable or performs inconsistently
- High specific activity on multiple animal cell lines

Figure 1. Comparison of the Activities of Universal Type I IFN, Human IFN Alpha 2a, and Mouse IFN Alpha A
Cat. No. |
Description |
Size |
11002-1 |
Human IFN Alpha (IFN-α) Sampler Set (subtypes also sold individually)* |
1 x 10^5 U |
11101-1, 2 |
Human IFN Alpha A (Alpha 2a), carrier-free |
5 μg, 20 μg |
11105-1 |
Human IFN Alpha 2 (Alpha 2b) |
1 x 10^5 U |
11175-1 |
Human IFN Alpha 1 (Alpha D) |
1 x 10^5 U |
11177-1 |
Human IFN Alpha 4a (Alpha M1) |
1 x 10^5 U |
11200-1, 2 |
Universal Type I IFN |
1 x 10^5 U, 1 x 10^6 U |
11395-1 |
Human IFN Omega |
25 μg |
11410-2 |
Human IFN Beta 1a, mammalian, carrier-free |
1 x 10^6 U |
11415-1 |
Human IFN Beta 1a, mammalian |
1 x 10^5 U |
11420-1 |
Human IFN Beta 1b, E.coli |
1 x 10^5 U |
11500-1, 2 |
Human IFN Gamma |
50 μg, 100 μg |
11720-1 |
Human IL-28A/IFN Lambda 2, HCE |
1 x 10^5 U |
11725-1 |
Human IL-29/IFN Lambda 1, HCE |
1 x 10^5 U |
11730-1 |
Human IL-28B/IFN Lambda 3, HCE |
1 x 10^5 U |
11821-1 |
Human IL-28A/IFN Lambda 2, carrier-free |
25 μg |
11826-1 |
Human IL-29/IFN Lambda 1, carrier-free |
25 μg |
*IFNa-A (2a); IFNa-B2 (8); IFNa-C (10); IFNa-D (1 [Val(114)]); IFNa-F (21); IFNa-G (5); IFNa-H2 (14); IFNa-I (17); IFNa-J1 (7); IFNa-K (6); IFNa-4b (4); IFNa-WA (16)
To learn more, please contact Info@2BScientific.com or call us at +44 (0)1869 238033!
Human Interferon Alpha (IFN-α) ELISAs
Featured:
Human IFN Alpha All Subtype ELISA (Cat. No. 41115)
High Sensitivity
- Assay Standard Range: 1.95 – 125 pg/ml
- Accurate low pg/ml detection of all human IFN-α subtypes
- Robust matrix tolerance including autoimmune disease sera, normal serum, and tissue culture media (TCM)
- Optimized for autoimmune serum and plasma samples
- Consistent, reproducible results with < 10% inter- and < 8% intra-assay CVs
- Detects previously “missed” IFN-α subtypes
Subtype |
LLOQ (pg/ml) |
LLOD (pg/ml) |
α1 (αD) |
2.31 |
0.76 |
α2a (αA) |
1.36 |
0.42 |
α4a (αM1) |
1.38 |
0.43 |
α5 (αG) |
1.70 |
0.51 |
α6 (αK) |
1.13 |
0.33 |
α7 (αJ1) |
2.09 |
0.59 |
α8 (αB2) |
2.81 |
0.82 |
α10 (αC) |
1.77 |
0.65 |
α14 (αH) |
1.76 |
0.51 |
α16 (αWA) |
2.01 |
0.68 |
α17 (αI) |
1.36 |
0.50 |
α21 (αF) |
6.18 |
1.67 |
Table 1. Lower Limit of Quantitation (LLOQ) and Lower Limit of Detection (LLOD) in Normal Human Serum.

Figure 2. IFN-α Specific Signal in Lupus Patients. Lupus patient serum number. Purple bars represent non-specific signal, i.e., signal not blocked by AntiIFN-α PAb.
Cat. No. |
Description |
Size |
41100-1, 2 |
VeriKine Human IFN Alpha ELISA Kit (TCM) |
1 x 96-well plate, 5 x 96-well plate |
41105-1, 2 |
VeriKine Human IFN Alpha Multi-Subtype ELISA Kit (TCM) |
1 x 96-well plate, 5 x 96-well plate |
41110-1, 2 |
VeriKine Human IFN Alpha Multi-Subtype Serum ELISA Kit (S, P, TCM) |
1 x 96-well plate, 5 x 96-well plate |
41115-1 |
VeriKine-HS Human IFN Alpha All Subtype ELISA Kit (S, P, TCM) |
1 x 96-well plate |
To learn more, please contact Info@2BScientific.com or call us at +44 (0)1869 238033!
Human Interferon Beta (IFN-β) ELISAs
Featured:
Human IFN Beta Serum ELISA (Cat. No. 41415)
High Sensitivity
- Assay Standard Range: 1.2 – 150 pg/ml
- Provides > 90% serum spike-recovery
- Reproducible results with < 8% inter- and intra-assay CVs
- Robust matrix tolerance for autoimmune disease sera
- Validated by multiple CROs for sensitive measurement of IFN-β therapeutics in human serum samples
- e.g. Rebif®, Avonex®, Extavia®, Betaseron®
- Suitable for PK, PD, Toxicity & Biomarker studies

Figure 3. ELISA Standard Curve in Normal Human Serum (NHS) vs. Standard Curve in Standard Diluent. No observable inhibitory effect of normal human serum.

Figure 4. Multiple Sclerosis (MS). IFN-β was measured in sera/plasma of Multiple Sclerosis (MS) patients and Normal Donors. IFN-β was found to be quantifiable in 86% of MS patients on IFN-β therapy, 4.1% of MS patients on other therapies, and 1.5% of Normal Donor samples.
|
41410 |
41415 |
● Good ● ● Better ● ● ● Best |
Hu-IFN-β |
Hu-IFN-β Serum |
Accurate IFN-β measurement in serum or plasma (including autoimmune disease sera) |
|
● ● ● |
Accurate IFN-β measurement in tissue culture media (TCM) |
● ● |
● ● ● |
Reproducible results with < 10% inter- & intra-assay CVs |
● ● |
● ● ● |
To learn more, please contact Info@2BScientific.com or call us at +44 (0)1869 238033!
Anti-Human IFN Monoclonal (MAb) & Polyclonal (PAb) Antibodies
Labeled & unlabeled antibodies for a variety of uses
- MAbs offer high specificity in applications where specific binding is desirable
- PAbs are preferable for neutralization because they target a variety of specific epitopes of a particular antigen
Featured: Anti-Human IFNAR2, Clone MMHAR-2 (MAb) (Cat. No. 21385-1)
- Blocks biological activity of human Type I IFNs and IFN-α receptor
- Binds to human IFN-α receptor with high affinity
Human Type I IFN Neutralizing Antibody Mixture (Cat. No. 39000)
Mixture of MAbs and PAbs directed against human Type I IFNs & IFNAR2
- Effectively neutralizes biological activity of human IFN-α, IFN-β, IFN-ω, IFN-κ, and IFN-ε
- Improves neutralization of multiple Type I IFNs often found in complex samples by employing a broadly neutralizing custom antibody cocktail

Figure 5. Mouse MAb to Human IFN-Alpha/Beta Receptor 2.

Figure 6. Representative neutralization curves (diluted 1:50) to human IFN-α, -β, and -ω. A549 cells incbated with antibody mixture and titrated IFN, subsequently challenged with EMCV.
Cat. No. |
Description |
Size |
Anti-Human IFN Alpha (MAb) (multiple clones available in varying sizes) |
21112-3 |
FITC Conjugated Anti-Human IFN Alpha, Clone MMHA-11 (MAb) |
25 μg |
21370-1 |
Mouse MAb against Human IFN Alpha/Beta Receptor 1, Clone MMHAR-3 (MAb) |
50 μg |
21370-3 |
R-Phycoerythrin (PE) Conjguated Mouse MAb against Human IFNAR1, Clone MMHAR-3 (MAb) |
50 tests |
21375-1 |
Anti-Human IFN Alpha/Beta Receptor 1, Clone MMHAR-1 (MAb) |
50 μg |
21375-3 |
PE Conjugated Anti-Human IFN Alpha/Beta Receptor 1, Clone MMHAR-1 (MAb) |
100 tests |
21376-3 |
CFS Conjugated Anti-Human IFN Alpha/Beta Receptor 1, Clone MMHAR-1 (MAb) |
100 tests |
21385-1 |
Anti-Human IFN Alpha/Beta Receptor Chain 2 (IFNAR2), Clone MMHAR-2 (MAb) |
50 μg |
21385-3 |
PE Conjugated Anti-Human IFN Alpha/Beta Receptor Chain 2 (IFNAR2), Clone MMHAR-2 (MAb) |
50 tests |
Anti-Human IFN Beta (MAb) (multiple clones available in varying sizes) |
21400-3 |
FITC Conjugated Anti-Human IFN Beta, Clone MMHB-3 (MAb) |
20 μg |
Anti-Human IFN Gamma (MAb) (multiple clones available in varying sizes) |
21585-1 |
Anti-Human IFN Gamma Receptor Chain 2, Clone MMHGR-2 (MAb) |
250 μg |
21720-1 |
Anti-Human IL-28A/IFN Lambda 2, neutralizing, Clone MMHL-2 (MAb) |
200 μg |
21730-1 |
Anti-Human IL-28B/IFN Lambda 3, neutralizing, Clone MMHL-3 (MAb) |
100 μg |
21885-1 |
Anti-Human IFN Lambda Receptor 1, Clone MMHLR-1 (MAb) |
50 μg |
21900-1 |
Anti-Human ISG15, Clone 2.1 (MAb) |
100 μg |
Anti-Human IFN Alpha (PAb) (multiple available) |
Anti-Human IFN Beta (PAb) (multiple available, including protein A or affinity purified) |
31500-1 |
Anti-Human IFN Gamma, Rabbit Serum (PAb) |
2 x 10^4 units |
39000-1 |
Human Type I IFN Neutralizing Ab Mixture |
0.2 ml |
To learn more, please contact Info@2BScientific.com or call us at +44 (0)1869 238033!