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Integrin Proteins

Integrin Proteins

Integrin Proteins

Background

Integrins are non-covalently-linked, heterodimeric molecules containing an α (120~185kD)and a β (90~110kD)subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains. As a group of cell-matrix adhesion molecules, integrins play important roles in cell survival, proliferation, motility, differentiation, and ensuring appropriate cell localization. Thus, it is predicted that integrins involve in both mechanical engagement of cell to extracellular matrix, and generation of cellular signals during cancer malignancies development.

ACROBiosystems has developed a comprehensive series of Integrin proteins expressed by HEK293, and AvitagTM biotinylated proteins can added your drug development. The proteins are suitable for ELISA, SPR, BLI and Cell based assay. ACRO has verified the purity and activity of the Integrin proteins, and organized the experimental operations and parameters into the corresponding protocol. Protocols are offered for free, which can help you save the development cycle.

Application

Product Features

Integrin proteins expressed by HEK293

Expression Systems Folding Phosphorylation Proteolytic Processing Glycosylation
E.Coli + N/A N/A N/A
Insect Cell ++ ++ ++ Poor
Plant Cell +++ +++ +++ Poor
CHO Cell ++++ ++++ ++++ Non-Human Like
Human Cell +++++ +++++ +++++ Human Authentic

High Bioactivity


Immobilized Fibronectin at 5 μg/mL (100 μL/well) can bind Biotinylated Human ITGAV & ITGB3 Heterodimer Protein (Cat. No. IT3-H82Wa) with a linear range of 0.078-1.25 μg/mL.


Immobilized Vitronectin at 5 μg/mL (100 μL/well) can bind Biotinylated Human ITGAV & ITGB3 Heterodimer Protein (Cat. No. IT3-H82Wa) with a linear range of 0.078-1.25 μg/mL.


Immobilized Human Fibronectin at 5 μg/mL (100 μL/well) can bind Biotinylated Human ITGA5 & ITGB1 Heterodimer Protein (Cat. No. IT1-H82Wa) with a linear range of 2-78 ng/mL.


Immobilized Human Fibronectin at 2 μg/mL (100 μL/well) can bind Human ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W5) with a linear range of 0.2-2 ng/mL.

High batch-to-batch Consistency


Immobilized Human Fibronectin at 2 μg/mL (100 μL/well) can bind Human ITGAV&ITGB1 Heterodimer Protein, His Tag & Tag Free (Cat. No. IT1-H52E1) with a linear range of 0.02-0.313 μg/mL.

Integrin proteins

alpha 1 beta 1

alpha 2 beta 1

alpha 2b beta 3

alpha 4 beta 1

alpha 4 beta 7

alpha 5 beta 1

alpha 6 beta 1

alpha 8 beta 1

alpha 9 beta 1

alpha 10 beta 1

alpha 11 beta 1

alpha E beta 7

alpha V beta 1

alpha V beta 3

alpha V beta 5

alpha V beta 6

alpha V beta 8

isoform alpha-7X2B

Ligands of Integrin proteins
E-cadherin LAP (TGF-beta 1)
MMP-2 Thrombospondin-2
ADAM12 VEGF-C
VEGF-D COMP
ADAM8 ADAM17

 

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