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Alzheimer’s Disease

Alzheimer’s Disease is a progressive neurodegenerative disease, causing symptoms such as memory loss and disorientation.

Alzheimer's disease (AD) is a major form of dementia, that accounts for up to 70% of cases of AD all over the world. Aging is the most important risk factor for this disease, which can be inherited as an autosomal dominant disorder with nearly complete penetrance in the case of early onset. As the disease progresses, loss of synapses is observed in association with tau (microtubule-associated proteins) and Aβ pathology (deposition of amyloid protein); neuronal loss occurs in the most affected areas, causing cognitive deficits such as language difficulties and disorientation.

The characteristics of AD neuropathology include accumulations of intracellular and extracellular protein aggregates. Abnormally phosphorylated tau assembles into paired helical filaments (PHFs) that aggregate into neurofibrillary tangles (NFTs) in the neuronal perikarya (cell soma, non-process portion of a neuron) and dystrophic neurites (abnormal neuronal processes). The second pathological hallmark of this condition is the extracellular deposition of β-pleated assemblies of Aβ peptides, forming diffuse senile plaques. The cleavage of amyloid precursor protein (APP) results in the formation of amyloid- β fibrils. The expression of voltage-gated potassium channels (transmembrane channels specific for potassium and sensitive to voltage changes) Kv 3.4 is up-regulated in the early stages of Alzheimer’s disease.  Despite the critical roles of Aβ and tau in AD pathology, drugs targeting Aβ, or tau have so far reached limited success.  

At 2B Scientific, we provide products that can help find novel genetic risk factors, disease mechanisms, candidate biomarkers for early diagnosis, and potential drug targets.

View all Alzheimer's Research Products  

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