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cancer; immune checkpoints; programmed cell death protein 1 (PD-1); programmed death ligand 1 (PD-L1)

Our Immune Checkpoint Partners

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  • Bio X Cell
  • ACROBiosystems
  • Arigo Bio

Programmed cell death protein 1 (PD-1), alternatively referred to as CD279, is an immunoglobulin superfamily member. It is expressed by activated T-cells and plays an important role in subsiding immune responses and promoting tolerance to self-antigens by suppressing T-cell activity. PD-1 has two natural ligands, known as PD-L1 (also known as CD274) and PD-L2 (CD273), that are mainly expressed by antigen presenting cells. Since over-expression of PD-L1 is common in many tumours, several monoclonal antibody therapeutics have been developed to block the PD-1/PD-L1 interaction. These include nivolumab (OPDIVO®) and pembrolizumab (Keytruda®), which have seen clinical success in treating melanoma.

PD-1 related antibodies from preferred suppliers:

Below are more purified versions

for more information on the differences between InVivoMAb and InVivoPlus please click HERE!

PD-1 related proteins from preferred suppliers:

PD-1 related Conjugated proteins:

PD-1 related ELISA kits from preferred suppliers:

PD-1 related Cell Lines from preferred supplier:

- M00552 - CHO-K1/mPD-1 Stable Cell Line - (Academic Discount Available) High protein expression at the cell surface validated by FACS. Stable cell lines for increased reliability and reproducibility (over 15 passages). Ready to use hot targets, saving 3-5 months of drug discovery program. For Binding Assay.