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CTLA-4

CTLA-4

Our Immune Checkpoint Partners

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  • Bio X Cell
  • ACROBiosystems
  • Arigo Bio
  • OriGene

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily. Expressed by T-cells, it binds to the ligands CD80 and CD86 on antigen presenting cells and subsequently inhibits T-cell activation. Ipilimumab (YERVOY™) is a recombinant human monoclonal antibody which blocks the interaction of CTLA-4 with its ligands and is approved by the FDA for the treatment of melanoma. Blocking CTLA-4 also has significant potential in treating conditions which include SLE, coeliac disease and autoimmune lymphoproliferative syndrome (ALS).

CTLA-4 related antibodies from preferred suppliers:

- BE0190 - InVivoMAb anti-human CTLA-4 (CD152) - The BN13 (clone) monoclonal antibody reacts with human CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152.

- BE0164 - InVivoMAb anti-mouse CTLA-4 (CD152) - The 9D9 (clone) monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152.

- BE0131 - InVivoMAb anti-mouse CTLA-4 (CD152) - The 9H10 (clone) monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152.

- BE0032 - InVivoMAb anti-mouse CTLA-4 (CD152) - The UC10-4F10-11 (clone) monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152.

 - TA355056 - Mouse Monoclonal Anti-CTLA-4 Antibody - Clone 1E6, CTLA-4 antibody was raised against the extracellular domain of human CTLA-4.

Below are more purified version:

for more information on the difference between InVivoMAb and InVivoPlus please click HERE!

- BP0164 - InVivoPlus anti-mouse CTLA-4 (CD152) - The 9D9 (clone) monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152.

- BP0131 - InVivoPlus anti-mouse CTLA-4 (CD152) - The 9H10 (clone) monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152.

- BP0032 - InVivoPlus anti-mouse CTLA-4 (CD152) - The UC10-4F10-11 (clone) monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. 

CTLA-4 related Proteins from preferred suppliers:

- BP0099 - InVivoPlus recombinant CTLA-4-Ig (hum/hum) - Purified from tissue culture supernatant in an animal free facility

- CT4-H52A4 - Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin - is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # NP_005205.2). This protein carries a mouse IgG2a Fc tag at the C-terminus.

- CT4-H5284 - Human CTLA-4 / CD152 Protein, Strep Tag - is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # NP_005205.2). This protein carries a twin strep tag at the C-terminus.

- CT4-M52H5 - Mouse CTLA-4 / CD152 Protein, His Tag - is expressed from human 293 cells (HEK293). It contains AA Glu 36 - Phe 162 (Accession # NP_033973). This protein carries a polyhistidine tag at the C-terminus.

- CT4-R5250 - Rabbit CTLA-4 / CD152 Protein, Fc Tag - is expressed from human 293 cells (HEK293). It contains AA Lys 36 - Asp 161 (Accession # P42072). This protein carries a human IgG1 Fc tag at the C-terminus.

CTLA-4 related Conjugated proteins:

- CT4-C82E5 - Biotinylated Cynomolgus / Rhesus macaque CTLA-4, Avi Tag (Avitag™) -  is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Ser 160 (Accession # G7PL88). In the region Ala 37 - Ser 160, the AA sequence of Cynomolgus and Rhesus macaque CTLA-4 are homologus. This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag.

- CT4-H82E1 - Biotinylated Human CTLA-4 Protein, His,Avitag™ - is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # Q6GR94-1). This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag.

- CT4-H82F3 - Biotinylated Human CTLA-4 Protein, Fc,Avitag™ -  is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # P16410-1). This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™).

CTLA-4 related ELISA kits from preferred suppliers:

- ARG81327 - Human CD86 ELISA Kit - for the quantification of Human CD86 in serum, plasma and cell culture supernatant. Sensitivity: 0.6 U/ml; Standard Range: 332 - 100 ng/ml. Recognizes natural Human soluble CD86. No cross reactivity with other Human soluble molecules.

- ARG81718 - Human CD80 ELISA Kit - Range: 714 - 100 ng/ml; linear range: 0.09 - 1.75 ng/ml; Sensitivity: 31.25 pg/ml