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CD40

CD40

Our Immune Checkpoint Partners

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  • Bio X Cell
  • ACRO Biosystems
  • Arigo Bio
  • Mabtech
  • OriGene

Belonging to the TNF-receptor superfamily, CD40 is expressed on the surface of B-cells and antigen presenting cells. Here it interacts with CD154 (also known as CD40 ligand or CD40L) on activated T-cells to stimulate a range of downstream events which include the initiation and progression of both cellular and humoral adaptive immunity. Dysregulation of CD40 signalling has been observed in autoimmune diseases such as type 1 diabetes, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis and SLE. CD40 is also widely studied for its role in cancer, with agonistic CD40 monoclonal antibodies showing promising anti-tumour effects.

CD40 related antibodies from preferred suppliers:

- BE0189 - InVivoMAb anti-human CD40 - The G28.5 (clone) monoclonal antibody reacts with human CD40 also known as Bp50.

- BE0017-1 - InVivoMAb anti-mouse CD40L (CD154) - The MR-1 (clone) monoclonal antibody reacts with mouse CD154 also known as CD40 ligand.

- BE0016-2 - InVivoMAb anti-mouse CD40 - The FGK4.5 monoclonal antibody reacts with mouse CD40 also known as Bp50.

- 3601-2-1000 - anti-human CD40 mAb S2C6, biotinylated - suitable for studies of CD40 expression on cells and tissue sections.

- TA807575 - CD40 Mouse monoclonal antibody - Clone OTI1F12, Human recombinant protein fragment corresponding to amino acids 21-166 of human CD40(NP_001241) produced in E.coli.

Below are more purified versions:

for more information on the differences between InVivoMAb and InVivoPlus please click HERE!

- BP0017-1 - InVivoPlus anti-mouse CD40L (CD154) - The MR-1 (clone) monoclonal antibody reacts with mouse CD154 also known as CD40 ligand.

- BP0016-2 - InVivoPlus anti-mouse CD40 - The FGK4.5 (clone) monoclonal antibody reacts with mouse CD40, also known as Bp50.

- 3621-1-250 - anti-mouse CD40 mAb CD40-A, purified - suitable for activation of mouse B cells. CD40-A, purified, supplied at 0.5 mg/ml in sterile filtered PBS and is free of preservatives

CD40 related proteins from preferred suppliers:

- TN5-M52H8 - Mouse CD40 / TNFRSF5 Protein, His Tag - is expressed from human 293 cells (HEK293). It contains AA Val 24 - Arg 193 (Accession # P27512). This protein carries a polyhistidine tag at the C-terminus.

- CD0-H5228 - Human CD40 / TNFRSF5 Protein, His Tag -  is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Arg 193 (Accession # P25942-1). This protein carries a polyhistidine tag at the C-terminus.

- CD0-H525a - Human CD40 / TNFRSF5 Protein, Mouse IgG2a Fc Tag, low endotoxin - is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Arg 193 (Accession # P25942-1). This protein carries a mouse IgG2a Fc tag at the C-terminus.

CD40 related conjugated proteins:

- CD0-H82E8 - Biotinylated Human CD40 / TNFRSF5 Protein, Avitag™,His Tag - is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Arg 193 (Accession # AAH12419.1). This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag.

- TN5-H82F9 - Biotinylated Human CD40 / TNFRSF5 Protein, Fc,Avitag™ - is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Arg 193 (Accession # P25942-1), this protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™).

CD40 related ELISA kits from preferred suppliers:

- ARG81438 - Human CD40 ELISA Kit - for the quantification of human CD40 in serum, plasma (heparin, EDTA), saliva, urine, human milk and cell culture supernatants.

- ARG81717 - Mouse CD40 ELISA Kitfor the quantification of mouse CD40 in serum, plasma (heparin, EDTA) and cell culture supernatants.

CD40 related Cell Lines from preferred supplier:

- M00606- Human Recombinant CD40 Stable Cell Line - (Academic Discount Available) High protein expression at the cell surface validated by FACS. Stable cell lines for increased reliability and reproducibility (over 15 passages). Ready to use hot targets, saving 3-5 months of drug discovery program. For functionality assay.

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