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Infection and Immunity

Infection and Immunity

Immune checkpoints function to regulate key pathways within the immune system. This is essential to control the amplitude and duration of an immune response as well as to maintain tolerance to self-antigens.

Researchers study immune checkpoints to better understand the role they play within immune homeostasis and to investigate ways of manipulating them to treat various disorders. Since many immune checkpoints are receptors which are activated by interaction with a ligand, the development of therapeutics to block immune checkpoints offers significant potential for the management of disease.

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