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Amyloid Beta 1-42 Oligomers

Additional Names:
Abeta Oligomers, Abeta peptide, Amyloid beta peptide oligomers, Beta amyloid peptide oligomers, amyloid beta precursor protein peptide oligomers, APP
Cell-based/Functional Assay, Western Blot
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Extra Details:
Our Amyloid Beta 1-42 (AB Beta42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (1,2). Our AB Beta42 oligomers present as globular oligomers when observed under TEM and AFM, and have a unique dimer/trimer and oligomer signal on a Western Blot with an anti-amyloid beta antibody. Our AB Beta42 oligomers were also demonstrated to be toxic to primary rat cortical neurons in a dose-dependent manner. In the brain, amyloid beta peptide (AB Beta) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of AB Beta plaques in the brain is considered a hallmark of Alzheimer's disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (3). Soluble AB Beta oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function (4). AB Beta oligomers generated in vitro were toxic to PC12 cells (5) and SH-SY5Y cells (6). AB Beta was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients (7) and accumulations of AB Beta were shown to be associated with lower survival rates in Parkinson's disease patients with dementia (8).
Gene Details:
Molecular Weight:
4.5 kDa
Protein Details:
Shipping Conditions:
Dry Ice
Storage Conditions:
StressMarq Biosciences
Proteins, Peptides, Small Molecoles & Other Biomolecules: Synthetic
2 x 100 ug
  • Manufacturer's Data Sheet:
Epitope Tag:
Long Description:
Human Synthetic Amyloid Beta 1-42 Oligomers
AAA;ABETA;ABPP;AD1;alpha-sAPP;alzheimer disease amyloid protein;amyloid beta (A4) precursor protein;amyloid beta A4 protein;amyloid precursor protein;amyloid-beta precursor protein;APPI;beta-amyloid peptide;beta-amyloid peptide(1-40);beta-amyloid peptide(1-42);beta-amyloid precursor protein;cerebral vascular amyloid peptide;CTFgamma;CVAP;peptidase nexin-II;PN2;PN-II;preA4;protease nexin-II;testicular tissue protein Li 2
Price for 2 x 100 ug £1057.00

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