Alpha Synuclein N-Terminal Acetylated Pre-formed Fibrils (Type 1) Product Size(s) 2 x 100 ug £893.00 SPR-332C Add to order Added to order Academic Pricing Please contact us for academic pricing. Contact Us About this Product SKU: SPR-332C Additional Names: Active tau PFFs, tau PFF, active tau protein Pre-formed Fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, mouse tau protein, P301S mutant tau, 2N4R tau, Tau441, fluorescent tau fibrils, ATTO 488 conjugated tau Application: Cell-based/Functional Assay, SDS-PAGE, Western Blot CE/IVD: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only. Extra Details: Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein purified from both normal and pathological brain tissue is N-acetylated (7) and this post-translational modification affects affect alpha-synuclein stability and toxicity (8). Gene Details: SNCA Molecular Weight: ~14.46kDa Protein Details: P37840 Purity: >95% Purification: Ion Exchange Shipping Conditions: Dry Ice Storage Conditions: -70[o]C Supplier: StressMarq Biosciences Type: Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins Size: 2 x 100 ug Manufacturer's Data Sheet: Epitope Tag: Untagged Accession: NP_000336.1 Need Help?