Alpha Synuclein A53T Mutant Monomers (Type 1) Product Size(s) 100 ug £555.00 SPR-325B Add to order Added to order Academic Pricing Please contact us for academic pricing. Contact Us About this Product SKU: SPR-325B Additional Names: A53T mutant alpha synuclein, A53T mutated SNCA, A53T Alpha synuclein monomer, Ala53thr mutant alpha synuclein, Active Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein monomers, SYN protein, Parkinson disease familial 1 Protein Application: Cell-based/Functional Assay, SDS-PAGE, Western Blot CE/IVD: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only. Extra Details: Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). The A53T mutation is a missense point mutation where alanine is replaced by threonine at the 53rd amino acid. This mutation has been linked to early-onset Parkinson's Disease and increased rates of alpha synuclein fibrillization. Gene Details: SNCA Molecular Weight: ~14.46 kDa Protein Details: P37840 Purity: >95% Purification: Ion Exchange Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA Shipping Conditions: Dry Ice Storage Conditions: -70[o]C Supplier: StressMarq Biosciences Type: Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins Size: 100 ug Manufacturer's Data Sheet: Epitope Tag: Untagged Accession: NP_000336.1 Need Help?