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Antibodies

ALK Antibody (pTyr1507): ATTO 488

Product Size(s)
100 ul
£540.00
SPC-913D-A488-100UL
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
SPC-913D-A488
Additional Names:
Alk Antibody, Anaplastic lymphoma kinase Antibody, CD246 Antibody, NBLST3 Antibody
Application:
Antibody Microarray, Western Blot
CE/IVD:
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Clonality:
Polyclonal
Conjugate:
ATTO 488
Extra Details:
ALK is a receptor-tyrosine kinase (belonging to the insulin receptor family) that is activated upon binding an unidentified ligand. Chromosomal rearrangments (most common), mutations, and amplifications in this gene are associated with numerous tumours including: anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. These fusion proteins, as well as other mutations and amplifications, likely confer hightened (possibly consititutive) kinase activity and thus promote cell growth and anti-apoptotic pathways such as the Akt MAPK pathways.
Host:
Rabbit
Immunogen:
A phospho-specific peptide corresponding to residues surrounding Tyr1507 of human ALK (AA1504-1510)
Purification:
Affinity Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C
Supplier:
StressMarq Biosciences
Type:
Antibody: Polyclonal Antibody
Specificity analysis using Rabbit Anti-ALK (pTyr1507) Polyclonal Antibody (SPC-913). Primary Antibody: Rabbit Anti-ALK (pTyr1507) Polyclonal Antibody (SPC-913) at 1:1000. Secondary Antibody: Anti-Rabbit IgG: HRP at 1:100000.WT Peptide Sequence: N-P-T-pY-G-S-W. SPOT peptide synthesis was used to perform substitution analysis of the phospho-acceptor AA in the sequence that was used to produce the phospho-site-specific antibody. The WT sequence corresponds to the original immunizing peptide sequence. Each spot represents the synthesis of ~10ug peptide that was identical except for the phosphoacceptor AA position.