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Cortisone CLIA Kit

SKU:
SKT-206-96
Academic Pricing:
Please contact us at info@2bscientific.com for specific academic pricing
Additional Names:
(8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione CLIA Kit
CE/IVD:
IVD
Extra Details:
Cortisone (C21H28O5, Kendall's Compound ‘E') was identified by Mason, Myers and Kendall in 1936 as Compound E extracted from bovine suprarenal gland tissue that had the qualitative but not quantitative activity of cortin. The presence of multiple cortin-like compounds led the authors to speculate that the study of Compound E would reveal the nature of cortin (1). Compound E is now called cortisone and the more active Compound F, cortisol, and the concentrations of these two glucocorticoids vary due to the activity of two 11ß-hydroxysteroid dehydrogenases (11-HSD) (2,3). While most tissues have the ability to express either enzyme, 11ß-HSD1 is found primarily in the liver where it converts cortisone to cortisol while 11ß-HSD2 is found in tissues such as the kidney where cortisol receptor binding is required. 11ß-HSD2 deactivates cortisol to cortisone, prohibiting receptor activation. This glucocorticoid “shuttle” helps to initiate and regulate the anti-inflammatory response, making cortisone one of the modern “wonder drugs”. onitoring the ratio of cortisone:cortisol has applications in diabetes, obesity, metabolic syndrome, osteoporosis, and chronic fatigue syndrome in addition to adrenal diseases (4-7). Cortisone and cortisol concentrations exhibit a predictable diurnal pattern and can be measured in extracted dried feces, or in serum, plasma, saliva and urine. A recent publication (8) has suggested that salivary cortisone is a good surrogate marker for serum cortisol.
Range:
78.1 - 20,000 pg/ml
Sensitivity:
10.6 pg/ml
Shipping Conditions:
Blue Ice
Storage Conditions:
4oC
Supplier:
StressMarq Biosciences Inc
Size:
96 well
  • Download:
Price for 96 well £490.00

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