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Antibodies

Anti-SENP1core Antibody

Product Sizes
Anti-SENP1core Antibody
£543.00
AB-0701-0250
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
AB-0701-0250
Additional Names:
sentrin/SUMO-specific protease SENP1;sentrin-specific protease 1;SUMO1/sentrin specific peptidase 1;SUMO1/sentrin specific protease 1;SuPr-2
Application:
Western Blot
Extra Details:
SENP1 is a SUMO isopeptidase that plays a critical role in the development of prostate cancer. SENP1 is overexpressed in prostate cancer samples. Overexpression of SENP1 in the prostate of mice leads to the development of prostatic intraepithelial neoplasia at an early stage. Consistent with the role of SENP1 in prostate cancer, it has demonstrated that overexpression of SENP1 enhances androgen-receptor mediated transcription. Inactivation of SENP1 in mice by retroviral insertion mutation is embryonic lethal (e12.5-e14.5) and leads to an increase in the steady state levels of SUMOylated forms of a number of proteins. Depletion of SENP1 levels in PC3 cells by RNAi leads to a decrease in cyclin D1 expression.
Gene Details:
SENP1
Host:
Chicken/Avian
Protein Details:
Q9P0U3
Reactivities:
Human
Shipping Conditions:
Dry Ice
Storage Conditions:
-20[o]C
Size:
250 ug
Supplier:
LifeSensors
Type:
Antibody