AEC5
About this Product
- SKU:
- PT-109
- Extra Details:
- AEC5 is a trimeric lipopeptoid with potent antifungal activity against Cryptococcus neoformans and Cryptococcus gattii and modest efficacy against other microbial pathogens. AEC5 rapidly reduces fungal burden in infected macrophages against C. neoformans, with nearly 50% reduction in fungal growth after 30 minutes and complete elimination of viable fungi within 3 hours. In mouse models AEC5 has an in vivo half-life of >20 hours and no observable toxicity following 28 days of daily injections.
- Molecular Weight:
- 521.7
- Purity:
- >96.2% by hplc
- References:
- <p>Corson (2016) Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. ACS Med Chem Lett. <strong>7</strong>(12) 1139 <a href="https://pubmed.ncbi.nlm.nih.gov/27994753/" target="_blank" rel="nofollow">PMID: 27994753</a><br></p><p>Spicer et al (2019) Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5. Biopolymers <strong>110</strong>(6) e23276 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660985/" target="_blank">PMID: 30938841</a></p>
- Sequence:
- Ntri-NLys-Nfur
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- >50 mg per ml in water
- Formula:
- C28H51N5O4