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Proteins and Peptides

AEC5

Product Sizes
AEC5
£212.00
PT-109
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
PT-109
Extra Details:
AEC5 is a trimeric lipopeptoid with potent antifungal activity against Cryptococcus neoformans and Cryptococcus gattii and modest efficacy against other microbial pathogens.  AEC5 rapidly reduces fungal burden in infected macrophages against C. neoformans, with nearly 50% reduction in fungal growth after 30 minutes and complete elimination of viable fungi within 3 hours.  In mouse models AEC5 has an in vivo half-life of >20 hours and no observable toxicity following 28 days of daily injections.
Molecular Weight:
521.7
Purity:
>96.2% by hplc
References:
<p>Corson (2016) Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. ACS Med Chem Lett. <strong>7</strong>(12) 1139 <a href="https://pubmed.ncbi.nlm.nih.gov/27994753/" target="_blank" rel="nofollow">PMID: 27994753</a><br></p><p>Spicer et al (2019) Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5. Biopolymers <strong>110</strong>(6) e23276 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660985/" target="_blank">PMID: 30938841</a></p>
Sequence:
Ntri-NLys-Nfur
Shipping Conditions:
Ambient
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Solubility:
>50 mg per ml in water
Formula:
C28H51N5O4